In a normal situation, yes.
But anytime Trump is in the mix, the rules change. EX: In the 2016 race, I voted for Cruz in the primary. Cruz was the true conservative and even then I was correctly concerned about Trump being polarizing. But because Cruz and Trump were at odds in the primary, the hardcore Trumpers turned on Cruz and got vicious with him. Trump actually financed the site Prntly, and they were the ones who floated the rumors about Cruz and prostitutes, which was not true but a lot of damage was done, and the hardcore Trumpers contributed to that. Ultimately, Trump defeated Cruz in the primary, and the rest is history.
I'm afraid the same thing will happen to DeSantis if he runs against Trump; the Trumpers will turn on him and try to destroy the man.